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pentobarbital will lessen the extent or effect of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Pitolisant exposure is lessened by 50% if coadministered with strong CYP3A4 inducers.pentobarbital will reduce the extent or outcome of ethotoin by influencing hepatic enzyme CYP2C9/10 metabol